Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7369
Gene Symbol: UMOD
UMOD 		0.200 GeneticVariation disease GWASDB Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases. 20686651 2010
Entrez Id: 51726
Gene Symbol: DNAJB11
DNAJB11 		0.310 Biomarker disease GENOMICS_ENGLAND DNAJB11-associated disease is a phenotypic hybrid of ADPKD and ADTKD, characterized by normal-sized cystic kidneys and progressive interstitial fibrosis resulting in late-onset ESRD. 29706351 2018
Entrez Id: 353
Gene Symbol: APRT
APRT 		0.310 Biomarker disease GENOMICS_ENGLAND Adenine phosphoribosyltransferase deficiency in children. 22212387 2012
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.600 Therapeutic disease RGD Although compelling evidence of a beneficial effect exists for the use of angiotensin-converting enzyme inhibitors (ACEIs) and low-protein diets, there is little evidence on whether carbon adsorbent has an effect on retardation of the progression of CRF. 14586729 2003
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.600 Biomarker disease RGD Only animals from the 1WIK group developed severe chronic renal failure, glomerulosclerosis, interstitial fibrosis, and upregulation of transforming growth factor-beta(1) (TGF-beta(1)) gene, which was associated with increased TGF-beta(1) protein expression in tubular epithelial cells, arterioles, and in areas of mononuclear interstitial cell infiltrate. 10919844 2000
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.600 Biomarker disease RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144 2014
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.600 Biomarker disease RGD Our findings indicate localized expression of MCP-1 in proximal tubular cells in the remnant kidney and suggest that MCP-1 in proximal tubular cells is involved in tubulointerstitial damage in chronic kidney failure associated with glomerular hypertension. 12080327 2002
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.600 Therapeutic disease RGD Sedentary CRF rats exhibited azotemia, hypertension, anemia, oxidative stress, activation of NF-kappaB and upregulations of reactive oxygen species-generating enzyme, NAD(P)H oxidase, MCP-1, cyclooxygenase-2 (COX-2), and PAI-1 in LV. 18797164 2009
Entrez Id: 57817
Gene Symbol: HAMP
HAMP 		0.570 Biomarker disease RGD Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. 20631677 2010
Entrez Id: 1535
Gene Symbol: CYBA
CYBA 		0.550 Biomarker disease RGD Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110 2009
Entrez Id: 51094
Gene Symbol: ADIPOR1
ADIPOR1 		0.530 Biomarker disease RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144 2014
Entrez Id: 5970
Gene Symbol: RELA
RELA 		0.510 Biomarker disease RGD Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction. 18077597 2008
Entrez Id: 1536
Gene Symbol: CYBB
CYBB 		0.510 Biomarker disease RGD Renal tissue abundance of gp91(phox) subunit of NAD(P)H oxidase was elevated in the untreated CRF group and was partially reduced in the iron dextran-treated CRF group. 15550752 2005
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1 		0.510 Therapeutic disease RGD An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. 26903149 2016
Entrez Id: 38
Gene Symbol: ACAT1
ACAT1 		0.500 Biomarker disease RGD Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. 19878707 2010
Entrez Id: 847
Gene Symbol: CAT
CAT 		0.500 Biomarker disease RGD Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. 20007347 2010
Entrez Id: 873
Gene Symbol: CBR1
CBR1 		0.500 Biomarker disease RGD Effect of experimental kidney disease on the functional expression of hepatic reductases. 25332430 2015
Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2 		0.500 Biomarker disease RGD Despite increased SREBP-2 gene expression we found LDL-receptor mRNA level to be lower than in controls, suggesting SREBP-2 independent mechanisms of LDL-receptor transcriptional regulation in CRF rats. 16814791 2007
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR 		0.500 Biomarker disease RGD Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. 21119529 2011
Entrez Id: 4036
Gene Symbol: LRP2
LRP2 		0.310 Biomarker disease RGD Modulation of gene expression by moxonidine in rats with chronic renal failure. 15266031 2004
Entrez Id: 5741
Gene Symbol: PTH
PTH 		0.300 Biomarker disease RGD Two novel vitamin D receptor modulators with similar structures exhibit different hypercalcemic effects in 5/6 nephrectomized uremic rats. 23548814 2013
Entrez Id: 5741
Gene Symbol: PTH
PTH 		0.300 Biomarker disease RGD The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. 21826734 2011
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1 		0.300 Biomarker disease RGD Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. 12089373 2002
Entrez Id: 5741
Gene Symbol: PTH
PTH 		0.300 Biomarker disease RGD Dietary phosphate binding and loading alter kidney angiotensin-converting enzyme mRNA and protein content in 5/6 nephrectomized rats. 22517117 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.300 Therapeutic disease RGD Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease. 29247650 2018